This paper presents a scheduling problem for unrelated parallel machines with sequence-dependent setup times, using simulated annealing (SA). The problem accounts for allotting work parts of L jobs into M parallel unrelated machines, where a job refers to a lot composed of N items. Some jobs may have different items while every item within each job has an identical processing time with a common due date. Each machine has its own processing times according to the characteristics of the machine as well as job types. Setup times are machine independent but job sequence dependent. SA, a meta-heuristic, is employed in this study to determine a scheduling policy so as to minimize total tardiness. The suggested SA method utilizes six job or item rearranging techniques to generate neighborhood solutions. The experimental analysis shows that the proposed SA method significantly outperforms a neighborhood search method in terms of total tardiness.