The aim was to identify the main risk factors for infection in patients with mandibular fractures located in the tooth-bearing area.Seven hundred and eighty-nine case histories were retrospectively reviewed regarding treatment results and nature of complications developed. The data concerning possible risks were analysed statistically to find out those factors that seemed to have a significant influence on the development of infection.The incidence of infection in patients with mandibular fractures located in the tooth-bearing area was determined by the following risk factors: social and organizational conditions of medical care, trauma pattern, preexisting medical status and treatment tactics. The main contributory factors were delayed medical care, accompanying pathological disorders, angular location, multiple and comminuted fractures and the type of antibiotic used.