To assess the neurodevelopmental health of children born after intracytoplasmatic sperm injection (ICSI).Prospective controlled blinded study.Tertiary care center.A total of 276 term-born singletons conceived by ICSI and 273 matched spontaneously conceived (SC) singletons at the age of 5.5 years.Neuromotor development assessed by a detailed neurologic examination, including the standardized motor test MOT 4–6, and emotional/behavioral development and intelligence assessed with the Kaufman-Assessment Battery for Children.There were no significant differences between ICSI children and control children regarding the neurologic examination, motor skills, emotional/behavioral development, and intelligence.The ICSI children born at term develop normally, similar to SC children.