Since the end of the Cold War, cross-border regions have proliferated at the borders of formal socialist countries, especially in China. Existing accounts of these emergences treat them either at the macro-level, focusing on political initiatives, or at the micro-level, with emphasis on social and economic relations. This paper uses the Taiwan–Suzhou cross-border region as a case study for suggesting a meso-level approach, arguing that as a result of continuous interactions between individual Taiwanese information technology firms and opportunity structures generated by the selective opening of the Chinese border, the formation of cross-border high-tech regions is shaped and determined at the level of the industrial system. The industrial system acts as a platform for coordination and cooperation between local elites and foreign investors and among individual firms within this system. The formation of the cross-border high-tech region thus involves the relocation and institutional re-embedding of industrial systems across the border, which has been accompanied by the systemic building of Taiwanese firms on the one hand, and the institutional innovation of Chinese local states on the other.