Several possibilities for obtaining high front-end resolution are demonstrated, in particular for collision-induced dissociation. In order to avoid residual excitation of the ion under investigation, it is necessary in such an experiment to avoid ejection of the nearby ions. This is why the difference method was used for the described experiments. The cyclotron frequency of an ion is dependent on its surrounding charge density; thus the number of ions in the cell must be drastically reduced if high front-end resolution is looked for. It is shown that under these conditions a front-end resolution of m/Δm > 30 000 can be reached for m/z 100. This can be obtained either by increasing the selectivity of the excitation, using longer duration and lower amplitude pulses, or by means of a two-dimensional experiment.