To study the impact about the stability and electronic properties on Sn 0.5 M 0.5 O 2 electrode (M=Ti, Mn, Sb and Pb), formation energies and electronic structures of mixed systems with same concentration are calculated using first-principles. Besides, the experiments data are compared with the calculated results. Results show the formation energies of solid solutions are −0.3117eV, 0.9379eV, 2.8443eV and 1.3652eV and all are higher than that of pure SnO 2 ; in addition, conductivity is improved after addition. Moreover, the computed results agree well with the foregoing experiments data. Therefore, the results of this paper provide a theoretical basis to development and application of Sn 0.5 M 0.5 O 2 electrodes.