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ET-1 induces vascular O 2− production via activation of NADPH oxidase. We have investigated whether c-Src and MAPKs activation are involved in ET-1-induced vascular oxidative response. At 2h, ET-1 induced an increase in NADPH oxidase-driven O 2− production in rat isolated aortic rings, which was completely suppressed in PP2 (c-Src inhibitor)-pretreated rings, whereas PP3...
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