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Peroxisome proliferator-activated receptors (PPARs) regulate the vascular cell functions as well as systemic lipid and glucose metabolism. Here, we studied the effect of TAK-559, a newly developed potent activator both for PPARα and γ, on the vascular cell recruitment. TNF-α - or interleukin-1β (IL-1β)-induced THP-1 cell attachment to cultured endothelial cells was significantly reduced in the presence...
In order to determine the influence of the lipid status on the ability of cholesteryl ester transfer protein (CETP) to modify the plasma lipoprotein profile, the effect of hypercholesterolemia versus hypertriglyceridemia were compared in wild-type and CETP-transgenic (CETPTg) rats expressing CETP at a constant level.Wild-type and CETPTg rats were fed either a chow diet, a high fat/high cholesterol...
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