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Mounting evidence indicates that alteration of apoptosis is involved in the mechanisms of cancer development. PUMA, a pro-apoptotic member of Bcl-2 family, mediates p53-dependent and -independent apoptosis.The aim of this study was to explore whether alteration of PUMA protein expression is a characteristic of human gastric carcinomas.We analysed expression of PUMA protein in 60 gastric adenocarcinomas...
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