From experimental results obtained in a wide range of operating conditions (temperature and contact time) in an isothermal fixed bed integral reactor, the validity both of the kinetic models proposed in the literature as well as their modifications, for the methanol-to-gasoline (MTG) process at zero time on-stream, has been studied. The kinetic parameters for the various models have been calculated by solving the equation of mass conservation in the reactor for the lumps of the kinetic models. The usefulness of the model of Schipper and Krambeck for simulating the operation in the isothermal fixed bed integral reactor has been proven in the 573–648 K range.