A 55year old male presented with abdominal pain and vomiting, followed by a sudden onset of left eye pain, with decreased visual acuity. After clinical and laboratory examinations, the patient was diagnosed with endogenous endophthalmitis, secondary to pyogenic liver abscess, secondary to Klebsiella pneumonia.The patient was managed with intravitreal injection of vancomycin and ceftazidime for 2weeks, which afforded a resolution.Cases of endogenous endophthalmitis pyogenic liver abscess are more commonly reported in the Far East. K. pneumonia primary liver abscess, particularly those associated with metastatic infection, are more commonly reported in Taiwan and are community acquired [1–3]. This paper reports the first case of endogenous endophthalmitis pyogenic liver abscess in the Middle East.