PFASs concentrations in dust samples collected from three microenvironments in Cairo ranged from 1.3 to 69 ng g−1 with FTOHs being dominant. The 8:2 FTOH was detected in all samples. Among the FOSAs and FOSEs the MeFOSE was dominant while among ionic PFASs, PFOS and PFOA were most prominent. The concentrations of PFASs were among the lowest worldwide. Correlations between worldwide concentrations of PFOS + PFOA and country development indexes highlight higher usage and human exposure in more developed countries. Food packaging was analyzed for PFSAs, PFCAs and PAPs. The 6:2 and 8:2 monoPAPs were found to be above the MDL in 18% of the samples. PFOA was detected in 79% of the samples with median concentration of 2.40 ng g−1. PFOS was detected in 58% of the samples with median concentration of 0.29 ng g−1 while PFHxS and PFDS were below detection limit. Different human exposure scenarios were estimated.