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Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matched controls were included. Information was collected on lifestyle, medical history,...
The elderly usually suffer from increased morbidity and mortality due to infectious diseases, and this process may be attributed to diminishing immune protection with age. This phenomenon is commonly referred to as immunosenescence. However, this theory is still not well defined. Non-human primates serve as a favorable model to facilitate the study in aging of the immune system. Here, we investigated...
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