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We recently demonstrated that numerical and functional alterations of γδ T cells are present in healthy elderly. Here we observed that the decreased absolute number of Vγ9Vδ2 T cells present in old subjects in comparison with young/adult and middle aged donors is due to the reduction of naive and central memory Vγ9Vδ2 T cells bearing CD27 and CCR7 antigens. The proportion of effector/memory Vγ9Vδ2...
A striking example of immunosenescence is seen in the honey bee (Apis mellifera) worker caste. The bees' age-associated transition from hive duties to more risky foraging activities is linked to a dramatic decline in immunity. Explicitly, it has been shown that an increase in the juvenile hormone (JH) level, which accompanies onset of foraging behavior, induces extensive hemocyte death through nuclear...
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