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Caloric restriction (CR) is effective in slowing aging and delaying aging-related diseases in many species, but the mechanism is complex and not fully elucidated. This study aimed to evaluate the beneficial effects of a caloric restriction diet on learning and memory, and further to elucidate the mechanisms. Thirty-six week-old male C57/BL mice were randomly divided into three groups: normal control...
Sarcopenic obesity (SO) is the comorbidity of age-related muscle wasting and obesity. SO increases the risk of heart disease, but little is known about the cellular signaling in cardiac muscle of SO individuals.The purpose of this study was to identify key cellular signaling alterations in cardiac muscle of sarcopenic obese mice.Thirty-two, male C57BL/6J mice were randomly divided into lean and high-fat...
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