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Expansion of CD4 + CD28 null , a common feature of immunosenescence, which has been reported in rheumatoid arthritis (RA) patients, may also be associated with a CD4 + imbalance. Although the increase of CD4 + CD28 null cells has been related to TNFα exposure, nothing is known about the possible role of genetic variants of this cytokine.Participants were genotyped...
Senescence – the progressive age-dependent decline in performance – occurs in most organisms. There is considerable variation in the onset and rate of senescence between and within species. Yet the causes of this variation are still poorly understood, despite being central to understanding the evolution of senescence. Long-term longitudinal studies on wild animals are extremely well-suited to studying...
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