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Amyloid-β (Aβ) peptides, the primary component of the amyloid plaques in Alzheimer’s disease (AD), exert profound effects on neurons in vitro and negatively impact on neuronal function in vivo. One of the consequences of increased Aβ in the brain, either as a result of overexpression of the precursor amyloid precursor protein in transgenic mice, or injection into the brain is a decrease in one form...
Glucocorticoid receptors (GR) regulate glial function, and changes in astrocyte gene expression are implicated in age-related pathology. We evaluated changes in astroglial GR expression in two strains of rats – Fisher 344 (F344; 4, 12 and 24months) and F344/Brown Norway strain (F344/BN; 4, 12 and 30months). In both strains basal levels of corticosterone were higher in the oldest groups of rats. Age-related...
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