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Glucocorticoids, the adrenal steroids secreted during stress, while critical for successful adaptation to acute physical stressors, can have a variety of deleterious effects if secreted in excess. It has come to be recognized that glucocorticoid excess can have adverse effects in the nervous system, particularly the hippocampus. These effects include disruption of synaptic plasticity, atrophy of dendritic...
Recently, PKC has been shown to play a pivotal role in physiological brain functions, connected with the memorizing processes and their correspondent progressive decline with brain aging. We have studied the age-dependent changes of PKC isoforms activity in connection with NOS expression and activity in specific brain areas such as hippocampus, cortex and striatum. Starting from middle aged rats,...
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