A large double-blind clinical trial in Austrian adolescents has confirmed the anticariogenic action of sodium trimetaphosphate. Compared with 926 subjects who used a product containing no anticaries agent, the 923 who used a toothpaste containing 3% of the phosphate had a 7.9% lower incidence of dental caries over a 3-yr period. The effect was more pronounced (an 11% reduction) in those subjects who brushed their teeth at least twice a day