This study investigates job satisfaction and stress in second career teachers (SCT) compared to first career teachers (FCT) and the role of self-efficacy in this context. Analyses are based on 297 teachers (35% SCT). SCT reported being highly satisfied and experiencing low levels of job stress. Moreover, t-tests revealed that SCT are more satisfied with their job than FCT. As the significant interaction self-efficacy and career path shows, self-efficacy has a higher impact on job stress in SCT than in FCT. Findings are discussed in terms of their relevance for the professional development of SCT.