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Two new bioactive mono-tetrahydrofuran (THF) γ-lactone acetogenins, asitrilobins C (1Figure 1Structures of 1 and 2 and their derivatives.) and D (2), were isolated from the seeds of Asimina triloba (Annonaceae) by directing the fractionation with brine shrimp lethality. Compounds 1 and 2 have a relative stereochemical relationship of threo/trans/threo across the mono-THF ring with its two flanking...
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