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Seven polycharged species, incorporating 1, 2, 3, 4 and 6 guanidine arms organized around a benzene core were synthesized and assayed as anti-mycobacterial agents against Mycobacterium tuberculosis. They display MIC values comprised between 25 and 12.5μM (close to ethambutol EMB) for the mono- and the hexa-substituted derivatives, and 0.8μM (close to isoniazid and streptomycin) for the tri-substituted...
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