Makyoh topography is applied to study the morphology of mechanically polished cross sections of renal stones. The results are compared to roughness and height profile data obtained by white-light interferometry, and to microstructure studies using optical and scanning electron microscopy. It is shown that Makyoh topography is able to furnish qualitative information on the surface roughness and height profile. Correlation with compositional data obtained by X-ray diffraction are established and discussed in terms of mechanical properties. Potential application for the study of the inner structure of the renal stones and implications for shock wave lithotripsy are discussed.