Two conflicting stratigraphic schemes describe the Siberian Karginskii interstade (Oxygen Isotope Stage 3 equivalent) as having: 1) relatively stable climate with environments more similar to the full glaciation; or 2) variable climate with landscapes that more closely approximate contemporary ones. New data from continuous lake cores and a nearly continuous section from western Beringia (WB) suggest that both schemes are valid. Herb-dominated communities, possibly with isolated populations of Larix, characterized northern WB with only a slight shift from relatively warm to cool summers during the mid-interstade. In contrast, herb and shrub tundra, steppe, forest-tundra, and modern Larix forest occurred at various times in areas of southern WB, suggesting greater climatic instability. A thermal optimum is evident in the south during the mid-interstade, with modern vegetation in southeastern WB and Larix forest-tundra in the southwest. Variations in Pinus pumila pollen indicate summer warm/winter dry and summer warm/winter wet conditions in southeastern WB. These fluctuations contrast to other areas of WB, where summers and probably winters were consistently arid. Although the interstade presents a unique interval within the Late Pleistocene, paleodata and paleoclimatic models suggest that changes in marine conditions, including sea level, were likely key drivers in the regional climate history.