The reaction mechanism for CO2 absorption in amine solvent was investigated by theoretical analysis. The reactants were CO2 and six amines, and the reactions were designed with or without additional water or amine molecule. These molecules increase the interaction between reactants and withdraw a proton from amino group of amine. From the additional amine model that shows lowest activation energy, zwitterionic and termolecular mechanisms seem to be suitable for CO2 capturing reaction in amine solvents. Moreover, the additional amine model can be applied to understand the enhancement effect of CO2 absorption in blended amine solvents. We report a new attempt that describes reaction mechanism in blended amine solvent by applying additional amine base. The results of CO2 capture ability were analogous to experimental observation. Comparing our results and previous QM/MM and ab initio MD calculations, it was found that the QM treatment including the reactants and surrounding water molecules would be very critical and the QM region should be properly selected large enough in QM/MM.