A mathematical model was developed to predict the coal bed methane (CBM) production and carbon dioxide (CO 2 ) sequestration in a coal seam accounting for the coal seam properties. The model predictions showed that, for a CBM production and dewatering process, the pressure could be reduced from 15.17 MPa to 1.56 MPa and the gas saturation increased up to 50% in 30 years for a 5.4×10 5 m 2 of coal formation. For the CO 2 sequestration process, the model prediction showed that the CO 2 injection rate was first reduced and then slightly recovered over 3 to 13 years of injection, which was also evidenced by the actual in seam data. The model predictions indicated that the sweeping of the water in front of the CO 2 flood in the cleat porosity could be important on the loss of injectivity. Further model predictions suggested that the injection rate of CO 2 could be about 11×10 3 m 3 per day; the injected CO 2 would reach the production well, which was separated from the injection well by 826 m, in about 30 years. During this period, about 160×10 6 m 3 of CO 2 could be stored within a 21.4×10 5 m 2 of coal seam with a thickness of 3 m.