Hollow MnFe2O4 nanoparticles were successfully synthesized based on simple galvanic replacement reaction with Mn3O4 as a precursor. The chemical composition and nanostructure of the as-prepared samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. MnFe2O4 was applied to decorate interdigital electrodes and the obtained sensors were used to detect fourteen kinds of volatile organic compounds at different operation temperature from 160°C to 280°C.Results show that the sensor has good sensitivity, repeatability and long-term stability for ethanol gas determination at 210°C. The detection linear range for ethanol is 2∼400ppm, and the response and the recovery time was 7.5s and 8.0s, respectively. Besides, the fabricated sensor also displayed decent performance in measuring n-decane in the concentration range of 2∼400ppm at 260°C. Finally, gas-sensing mechanism of the prepared sensor was clearly studied.