Polymerization of a tetrafunctional monomer was investigated under a variety of photoinitiation conditions to assess the ability to form thick materials in situ for orthopaedic applications. The major biological concerns include local cell and tissue necrosis due to the polymerization exotherm and low conversions at greater depths due to light attenuation through thick samples. Experimental results indicate that depth of cure and temperature rises are controllable by altering the photoinitiator concentration, initiating light intensity, and type of photoinitiator. For example, no measurable conversion was detected at a 1.0cm depth when polymerization was initiated with 1.0wt% DMPA and 100mW/cm 2 ultraviolet light, whereas ~40% conversion was obtained when the initiator concentration was lowered to 0.1wt%. This conversion was further increased to ~55% when a photobleaching initiator system was employed. At the highest rate of initiation studied (i.e., 1.0wt% DMPA irradiated with 100mW/cm 2 ultraviolet light), a maximum temperature of ~49 o C was reached at the sample surface; however, this temperature dramatically decreased to ~33 o C when the light intensity was decreased to 25mW/cm 2 . Finally, dual initiating systems that synergistically combine the advantages of photoinitiation and thermal initiation were investigated.