Purpose: Recently we have found that betaendorphine a potent opioid peptide depressed and completly changed the shape of FVER of rats, proportionally to the intracerebroventricular /icv/ dose used. The aim of present study was to find out if DAMEA, another opioid receptor agonist acts like betaendorphine and if NE affects it.Methods: The experiments were carried out on 20 white rats, stereotaxically implanted with polyethylene cannulas into lateral brain ventricle /icv/ and with active under and reference electrodes on the skull. Three days later the FVER were recorded by the 1000 LKC electrophysiologically interfaced personal computer system /USA/, with ganzfield stimulation of both mydriaric eyes, under chloral hydrate anaesthesia.Results: DAMEA in doses 20,50,100 and 200nM injected icv depressed and changed the shape of FVER proportionally to the dose used. Injection of 40nM of NE restored the amplitude of C wave during 5 to 25 min.Conclusion: DAMEA modulates FVER in rats similarly to betaendorphine but at the 10 to 20 times higher doses. NE restored the diminished by DAMEA FVER, perhaps by stimulating the adrenergic receptors of the brain.