The interfacial tension of poly lactic acid (PLA) melt is measured in supercritical carbon dioxide (CO 2 ) at the temperature range of 143°C to 168°C and CO 2 pressures up to 13,790kPa, using axisymmetric drop shape analysis profile (ADSA-P). The results show a decrease in interfacial tension with increasing temperature and pressure. However, the interfacial tension dependency on temperature at high pressures decreases because of a reduction in CO 2 solubility at high temperatures. The relationship between the interfacial tension and the density-difference of polymer-supercritical CO 2 mixtures is also examined by the generalized Macleod’s equation. Moreover, the range of stability for the melted drop, in interfacial tension measurements, is obtained by dimensionless Bond number. The results indicate the validity of the measurements for Bond number between 0.36 and 0.48.