Fixture preparation and NC data generation are unavoidable operations for effective implementation of flexible manufacturing systems in high product mix and low-volume prismatic components. By developing new technologies for automatic fixture preparation and NC data generation, using flexible manufacturing systems should lead to high-efficiency manufacturing for small batches. Fixture-free machining, especially for block-like and plate-like components, was considered, and new machining centers were developed. The machining centers require CAD/CAM systems to automatically generate NC programs. By combining the machining centers and CAD/CAM systems, fully automated manufacturing can be performed for block-like and plate-like prismatic components. Research on fixture CAD/CAM systems to support the design of fixtures for complex prismatic workpieces, such as welded, forged, and cast materials, is also discussed.