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It is important to understand the mechanisms by which a deep inspiration (DI) affects bronchoconstriction in rodents so that their relevance as animal models of asthma can be assessed. We investigated the effect of DI on respiratory input impedance after methacholine inhalation in four groups of rats: a control group, a group receiving DI prior to challenge, and two groups receiving different degrees...
The contributions of respiratory and conducting airway asymmetry, gas exchange, and non-uniform ventilation to the sloping alveolar plateau in phase III of the gas washout curve are investigated using mathematical models of the human lung. The models range from fully symmetric, to a detailed asymmetric conducting airway model coupled with 29 445 lumped parameter respiratory airway models. A gas transport...
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