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Normal phase liquid chromatography combined with particle beam mass spectrometry has been applied to the analysis of fluconazole, an anti-fungal agent, [2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ol] and a related intermediate, UK-51060 [2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-ethan-2-one]. Electron ionisation and chemical ionisation have been investigated in combination...
A new, simple, precise, rapid and stability indicating RP-HPLC method has been developed for the simultaneous determination of mebendazole and pyrantel pamoate from tablets. Chromatography was carried out on a Shodex C8 column using a mixture of 0.05 M monobasic sodium phosphate: acetonitrile: triethylamine (60:40:1.5, v/v), adjusted to pH 6.8 with phosphoric acid. Detection was carried out at 290...
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