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A new synthesized fluorescent probe, 1,3,5,7-tetramethyl-8-(3',4'-diaminophenyl)-difluoroboradiaza-s-indacence (TMDABODIPY), has been used to detect nitrite. When TMDABODIPY reacted with nitrite, a weak fluorescent triazole formed in 0.2 mol l -1 HCl medium at room temperature. The fluorescence quenching intensity was linear over a nitrite concentration of 0.04-0.32 μmol l -1...
The synthesis of a novel fluorescent probe, 3-epoxypropoxy fluorescein (EPF), and its properties for labeling of histidine are described. The probe contained a fluorescein fluorophore with long-wavelength response and an active epoxy labeling group. In alkaline media EPF reacted selectively with histidine, rather than with other amino acids, causing a large increase in fluorescence intensity and thereby...
A new fluorescent probe 1,3,5,7-tetramethyl-2,6-dicarbethoxy-8-(3′,4′-diaminophenyl)-difluoroboradiaza-s-indacene (TMDCDABODIPY) has been developed to detect nitrite in meat products and vegetables. The fluorescence of TMDCDABODIPY is very weak, but when it reacts with nitrite, a strong fluorescent triazole forms in aqueous medium at room temperature, which offers the advantage of specificity and...
Salicylaldehyde hydrazones of 1 and 2 were synthesized and their potential as fluorescent probes for zinc ion was investigated in this paper. Both of the probes were found to show fluorescence change upon binding with Zn 2+ in aqueous solutions, with good selectivity to Zn 2+ over other metal ions such as alkali/alkali earth metal ions and heavy metal ions of Pb 2+ , Cd ...
A ratiometric fluorescent probe 1 for fluoride ion was developed based on modulation of the excited-state intramolecular proton transfer (ESIPT) process of 2-(2′-hydroxyphenyl)benzimidazole (HPBI) through the hydroxyl group protection/deprotection reaction. The probe 1 was readily prepared by the reaction of HPBI with tert-butyldimethylsilyl chloride (TBS-Cl) and shows only fluorescence emission maximum...
Triphenylmethane (TPM) dyes normally render rather weak fluorescence due to easy vibrational deexcitation. However, when they stack onto the two external G-quartets of a G-quadruplex (especially intramolecular G-quadruplex), such vibrations will be restricted, resulting in greatly enhanced fluorescence intensities. Thus, TPM dyes may be developed as sensitive G-quadruplex fluorescent probes. Here,...
A new Rhodamine-based chemosensor RBSN designed for the selective detection of Hg 2+ in aqueous media is synthesized and structural characterized. It features brightness blue emission in the presence of Hg 2+ with the fluorescent detection limit for Hg 2+ in aqueous media being ppb levels and exhibits excellent Hg 2+ -specific luminescence enhancement over various competitive...
A novel fluorescent probe is designed and synthesized for the determination of cysteine in biological samples by incorporating 2,4-dinitrobenzenesulfonyl (DBS) group as a quencher into the BODIPY skeleton. The BODIPY-based probe itself shows weak fluorescence due to the strong intramolecular charge transfer process. Upon reaction with cysteine, however, the probe produces a rapid and large fluorescence...
CdTe quantum dots (QDs) were used as a highly selective probe for the detection of prion protein. Orange-emitting precipitates appeared within 30s of the addition of recombination prion protein (rPrP) to a solution of green-emitting CdTe QDs. This allowed colorimetric qualitative and semi-quantitative detection of rPrP. The decrease in fluorescence intensity of the supernatant could be used for quantitative...
The CdS/TiO 2 –fluorescein isothiocyanate (FITC) luminescent nanoparticles (CdS/TiO 2 –FITC) with the particle size of 20nm have been synthesized by sol–gel method. CdS/TiO 2 –FITC could emit the fluorescence of both FITC and CdS/TiO 2 . The fluorescence resonance energy transfer (FRET) occurred between the donor CdS/TiO 2 and the acceptor FITC in the CdS/TiO...
Water-soluble and luminescent ZnO quantum dots (QDs) capped by (3-aminopropyl) triethoxysilane (APTES) are environment-friendly with strong photoluminescence (max. wavelength: 530nm). Interestingly, it was found that the fluorescence could be quenched by dopamine (DA) directly. On the basis of above, a novel ZnO QDs based fluorescent probe has been successfully designed to detect DA with high selectivity...
A method is proposed for the detection of Hg 2+ using Hg 2+ specific DNA (MSD) functionalized gold nanoparticles (AuNPs) based on the formation of T–Hg 2+ –T complex and the excellent quenching fluorescence property of AuNPs. The MSD is rich in thymine (T) and readily forms T–Hg 2+ –T configuration in the presence of Hg 2+ . The MSD which is labeled with a fluorescein...
Three multi-branched rhodamine based fluorescent probes TPARH1-3 have been designed and synthesized by incorporating the rhodamine fluorophore with triphenylamine. The probe TPARH1 displayed high sensitivity to Cu 2+ in aqueous CH 3 CN. The probes TPARH2 and TPARH3 showed high sensitivity towards Hg 2+ in aqueous EtOH medium as reflected by their signalling responses. The cooperative...
A coumarin-based multifunctional fluorescent sensor containing a di-2-picolylamine (DPA) moiety (1) was presented. Interestingly, this probe could similarly act as ON-OFF type fluorescent sensor for Co 2+ and Cu 2+ , then in situ generated 1-Co(II) and 1-Cu(II) ensembles could further serve as OFF-ON type fluorescent sensors to achieve the discrimination of Zn 2+ from Cd ...
Two water soluble fluorescent probes with quaternary ammonium salts as solubilization groups were designed and synthesized to detect proteins with close mercapto groups. The unique structure of V-shape oligo(o-phenylene-ethynylene) backbone connecting two maleimide groups as mercapto group recognition sites enables the probes to distinguish a single mercapto group from two close mercapto groups in...
Development of fluorescent probes for Hg 2+ has become a hot topic in modern chemical research due to its high toxicity. In this paper, we for the first time report the synthesis and application of a thioether spirocyclic rhodamine B derivative (TR) as an efficient fluorescent probe for Hg 2+ . TR was synthesized using a simple procedure under mild condition. By employing a thioether...
We have developed a simple, rapid and label-free sensor for the essential biological OH radicals based on the fluorescence quenching of DNA-templated Ag nanoclusters (DNA-Ag NCs). The OH radicals generated from the Fenton reagent attack and cleave the DNA template, which disturbs the microenvironments around Ag NCs, resulting in spontaneous aggregation due to the lack of stabilization and further...
We herein report a turn-on fluorescent probe based on excited state intramolecular proton transfer (ESIPT) mechanism and self-immolative linker for hydrogen sulfide detection. The new probe exhibits high sensitivity and selectivity over other biologically relevant anions. Moreover, we show the utility of the probe for the detection of hydrogen sulfide in living cells as well.
We reported a two-photon ratiometric fluorescent probe for detecting intracellular pH. When excited with 800nm laser, an optimal output of laser as the routine equipment of two-photon fluorescence microscopy, the two-photon excited fluorescence of this probe showed distinct emission peak shift as large as 109nm upon the change of pH values in vitro. Very importantly, the experiment results show that...
A novel highly selective and sensitive fluorescent probe (NJ1) had been designed and synthesized for Cu 2+ detection by fluorescence quenching mechanism, and then the enhancement of fluorescence intensity with the addition of hydrogen sulfide in complex NJ1Cu aqueous solution at physiological conditions were described. This “on–off–on” type fluorescence recognition system was a reversible...
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