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We examined a possible role for heat shock factor-1 (HSF-1) in the negative regulation of HO-1 gene expression in human Hep3B hepatoma cells responding to stimulation with 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ) and arsenite. Overexpression of HSF-1 and heat-shock experiments indicated that HSF-1 repressed the 15d-PGJ 2 -and arsenite-induced HO-1 gene expression...
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