This is a study of lectin and mucilage detection in Colombian Labiatae nutlets. It was carried out on 40 taxa belonging to six genera, concerning which no previous studies have been carried out in this field. A differential response was observed in the group of genera and species studied, in terms of mucilage presence as well as lectin activity which consistently increased following extract treatment with Pectinex. Lectin activity was detected in more than 80% of the species, being important (greater than 60% activity) in at least half of the species. Genera such as Hyptis or Lepechinia, whilst not presenting mucilage, did present lectin activity. In contrast, Salvia (in all sections studied) presented mucilage and important lectin activity. In some species, such as S. rubescens, notable intraspecific variations in mucilage and lectin activity were detected; this could have taxonomic relevance. No direct correlation could be established between a class of biotype or a particular habitat having greater lectin activity.