A dendrite reinforced metallic glass matrix composite: Ti 48 Zr 20 Be 15 V 12 Cu 5 exhibits distinguished work hardening during dynamic plastic flow, accompanied by the ultimate strength of 2700MPa and the maximum fracture strain of 10.6%. The large plasticity is macroscopically accommodated by the “ductile framework”, microscopically characterized by multiple dislocations and severe lattice distortion within dendrites. To our knowledge, the present results are the first to get a distinguished work-hardening capacity and to elucidate the flow mechanism of in-situ dendrite reinforced metallic glass matrix composites upon dynamic compression.