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The twin screw extruder has recently become popular as a continuous wet granulation technique. It is logical that granulation using a twin screw granulator will depend on several process variables including powder feed rate but little is known about how these variables will affect the kinetics and mechanisms of granule growth and the eventual structure. The work focuses on understanding how granule...
Understanding the relationship between high shear wet granulation processing parameters and the characteristics of intermediate and final products is crucial in the ability to apply quality by design (QbD) and process analytical technologies (PAT) to secondary pharmaceutical processes. This research examined a high shear wet granulation process and subsequent manufacturing of a tablet containing a...
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