Intact and heat-treated synthetic aluminum silicates (SAS) were used to investigate the change in crystalline properties and the solid-state reaction of succinic anhydride and p-nitroaniline mixed with SAS. Heat-treated SAS was obtained by heating at 850°C for 3 h. Pore volume and specific surface area of SAS heated at 120°C (SAS120) were much greater than those of SAS heated at 850°C (SAS850). From the powder X-ray diffraction measurement, it was found that the mixing of organic compounds with SAS caused changes in their crystalline state. The ability of SAS120 for changing organic components from crystal to amorphous state was greater than that of SAS850. Extreme acceleration of the addition reaction between succinic anhydride and p-nitroaniline was observed when mixed with SAS. The acceleration of the reaction can be explained in terms of the adsorption of organic molecules in the pores of SAS and the surface acidity of SAS.