The relationship between cardio-ankle vascular index (CAVI) and components of metabolic syndrome (MetS), in addition to age and sex as confounders was explored to verify the characteristics of CAVI.A cross-sectional study was conducted for 144 subjects (108 males and 36 females), aged 31–86 years, who were inhabitants undergoing intensive health checkups. Multiple logistic regression analysis was performed to analyze the association.MetS was present in 36 of 108 males (33%) and 13 of 36 females (36%). Significant association between CAVI≥9 and male subjects or age was recognized. Although five metabolic components did not show any significant association with CAVI≥9, there was a trend of positive association between CAVI and BMI<25 (p=0.060), high blood pressure (p=0.074) or hypertriglyceridemia (p=0.088).Male and age were significantly associated with CAVI≥9. Further study is needed to verify the association between CAVI≥9 and MetS components.