Crystallisation of acetaminophen in the presence of polyvinylpyrrolidone (PVP) caused a marked enhancement of its dissolution rate. By increasing the molecular weight and/or the concentration of PVP in the crystallisation medium, the obtained crystals exhibited faster dissolution. This enhancement was attributed to the absorption of PVP on the surface of the acetaminophen crystals, which increased their wettability. This was confirmed by measuring the contact angle between water and the acetaminophen surface. A decrease in the crystal size of acetaminophen obtained in the presence of PVP may have also contributed to the higher dissolution rate. It was shown that the solubility of untreated acetaminophen increased in solutions containing PVP. However, there was no significant difference between the solubility of untreated acetaminophen and that of samples crystallised in the presence of PVP. The amount of PVP in the acetaminophen particles was far below that required to produce a significant concentration in the dissolution medium for increasing acetaminophen solubility.