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The predictions of the 'Linear Transfer Model' (LTM) have been tested only by modulating the frequency of the action potentials while keeping the size of the activated neuronal population constant. The LTM states that the blood oxygenation level-dependent contrast (BOLD) signal is directly proportional to the neuronal activity averaged over milliseconds or seconds. We examined the influence on the...
We re-analyzed the functional magnetic resonance imaging data from a study involving awake, adult, human volunteers in order to examine the influence of vascular density on the blood oxygenation level-dependent (BOLD) response. We employed a flashed and reversing stimulus paradigm where the latter stimulated twice the number of receptive fields and with it doubled the neuronal metabolic load (CMRO...
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