A method for quantifying perhalogenated compounds with the general formula C x Br y Cl z (where x=1 or 2 and y+z=4 or 6) by high-performance liquid chromatography (HPLC) was developed. The interest in such a determination by HPLC is related to the use of mild conditions, avoiding possible compound decomposition from the higher temperatures used in gas chromatography. Analytical curves were obtained using both the external calibration and the internal standard (CHCl 3 ) methods. The detection limits for CBr 4 , CCl 4 , C 2 Br 4 , C 2 Cl 4 , CBrCl 3 , C 2 Cl 6 and C 2 Br 2 Cl 4 were, respectively, 2, 4, 1, 1, 1, 5 and 2 mg l - 1 . For determination of unknown samples, the internal standard method is preferred as several standard solutions proved to be unstable in methanol-water solution.