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An automated system for the enantiopurity test of S-perindopril based on the concept of flow injection with an amperometric biosensor (based on l-aminoacid oxidase) is described. The system is suitable for the on-line monitoring of S-perindopril at a sampling rate of 65 samples per h, in the linear range: 200 pmol l -1 -80 nmol l -1 with an RSD better than 0.09% (n=10).
Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia