An increasing frequency of nutrition-related disorders within New Zealand led us to consider whether a realistic and sustainable group intervention in the workplace could improve risk factors. In 12 healthy volunteers, measurements were made at 0, 3, 6, and 9 weeks of the study. At week 3, all participants received group advice to change diet and physical activity. At week 6, 6 randomly selected volunteers consumed a daily dose of kiwifruit and the other 6 were asked not to eat kiwifruit, but all were encouraged to continue lifestyle change. Measurements included administration of food frequency and physical activity questionnaires, fasting plasma glucose, insulin and lipids, and recording of pedometer steps in weeks 3, 6, and 9. Cancer risk was assessed using the single cell electrophoresis assay in leukocytes following a challenge with the known strand-breaking agent, hydrogen peroxide. The reported diet and level of physical exercise were improved postintervention, but there were no significant effects on plasma glucose, insulin, and lipids, and no overall weight reduction. Although the measured levels of DNA damage were not affected by entry to the study nor by dietary or exercise advice, regular kiwifruit consumption led to a significant increase in the ability of leukocytes to repair DNA breakage by free radicals (P < .008). “Prescription” of daily kiwifruit may provide a sustainable population intervention that could reduce some of the risk factors associated with cancer. However, more aggressive interventions may be necessary to reduce the risk of other lifestyle diseases.