Lysophosphatidic acid (LPA) receptor has been attracting many neuroscientists' concerns, since it was reported to have a potential role in the neurogenesis, which occurs in the ventricular zone of the developing and adult brain. In the present experiments using baculovirus expression system, the LPA receptor encoded by ventricular zone gene 1 (Edg-2/Vzg-1) was found to be functionally coupled to G i 1 , G o a , and G 1 1 , but not to G S . The coexpression of LPA receptor markedly decreased the expression of G protein α i 1 or α o a subunit, while the basal [ 3 5 S]GTPγS binding significantly increased in the G i 1 -preparation. The Scatchard Plot analysis indicates that the expression of LPA-receptor (Edg-2/Vzg-1) showed stimulation of G i 1 without agonist. These results suggest the Edg-2/Vzg-1 has an intrinsic acctivity on G i 1 .