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As a first step toward the development of 99m Tc PiB analogs, we have synthesized six neutral Re 2-phenylbenzothiazoles via pendant or integrated approach. These Re compounds bind to Aβ 1–40 fibrils with fairly good affinities (K i =10.0–88.6nM) and have moderate lipophilicities (logP C18 =1.21–3.26). The Re compounds prepared via the integrated approach are smaller...
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