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Antagonism of orexin receptors has shown clinical efficacy as a novel paradigm for the treatment of insomnia and related disorders. Herein, molecules related to the dual orexin receptor antagonist filorexant were transformed into compounds that were selective for the OX 2 R subtype. Judicious selection of the substituents on the pyridine ring and benzamide groups led to 6b; which was highly...
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