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A finite element model of the knee meniscus was developed to investigate the effects of various geometrical and material properties on the behaviour of the meniscus under compressive load. Factorial methods were used to determine the relative effect of varying the properties by +/-10% of their initial value. It was found that the stresses in the meniscus were more sensitive to geometry (meniscus width and radius of curvature of the femoral surface of the meniscus) than material properties. The model was also used to investigate the effect of incongruency between the radius of curvature of the femur and the femoral surface of the meniscus. It was shown that mismatch between the curvatures of the femur and meniscus has a large effect on the stresses both in the meniscus and in the underlying cartilage. The results from the study have implications for the design and development of meniscal repair devices and replacements.