In recent years cryogenic cooling based on Liquid Nitrogen has been adopted to improve the titanium alloys machinability mainly in rough operations. However, when applied to semi-finishing machining, the very low temperatures may significantly affect the component final geometry. To this aim, the paper presents the thermal-mechanical modeling of a new tool holder properly designed to reduce the component geometrical deviations from its nominal geometry during cryogenic machining. The model was calibrated and validated through turning trials on wrought Ti6Al4V samples, proving a reliable prediction of the tool holder behavior during cryogenic machining.